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Escudero CA1,2, Herlitz K1, Troncoso F1, Guevara K1, Acurio J1, Aguayo C2,3, Godoy AS4,5, González M2,6. Abstract The underlying molecular mechanisms involve in the regulation of the angiogenic process by insulin are not well understood. In this review article, we aim to describe the...

Aguilera V1, Briceño L1, Contreras H2, Lamperti L1, Sepúlveda E1, Díaz-Perez F1, León M1, Veas C1, Maura R3, Toledo JR3, Fernández P4, Covarrubias A5, Zuñiga FA1, Radojkovic C1, Escudero C6, Aguayo C7. Abstract BACKGROUND: Mesenchymal stem cells have a high capacity for tra...

Escudero CA1. Development of placental vascular tree is structurally and functionally required for both adequate placental growth and delivery of nutrients from mother to the fetus. Impaired placental angiogenesis has been implicated in the pathophysiology of pregnancy complications which have im...

Cumsille P1,2,3,4, Coronel A5,6, Conca C7,8, Quiñinao C9, Escudero C10,11,12. Abstract One of the main challenges in cancer modelling is to improve the knowledge of tumor progression in areas related to tumor growth, tumor-induced angiogenesis and targeted therapies efficacy. For this pur...

Veas C1, Jara C, Willis ND, Pérez-Contreras K, Gutierrez N, Toledo J, Fernandez P, Radojkovic C, Zuñiga FA, Escudero C, Aguayo C. Abstract Human endothelial progenitor cells (hEPC) are adult stem cells located in the bone marrow and peripheral blood. Studies have indicated that hEP...

Abstract Mesenchymal stem cells (MSCs) are adult multipotent stem cells that are able to differentiate into multiple specialized cell types including osteocytes, adipocytes, and chondrocytes. MSCs exert different functions in the body and have recently been predicted to have a major clinical/th...

Acurio J1, Herlitz K1, Troncoso F1, Aguayo C2,3, Bertoglia P4, Escudero C5,6. Abstract We aim to investigate whether A2A/nitric oxide-mediated regulation of vascular endothelial growth factor (VEGF) expression is impaired in feto-placental endothelial cells from late-onset pre-eclampsia...

Abstract HIGHLIGHTS Short-term incubation with insulin increases the L-arginine transport in HUVECs.Short-term incubation with insulin increases the NO synthesis in HUVECs.Insulin induces relaxation in human placental vascular bed.Insulin attenuates the constriction induced by hydrogen peroxid...