Yearly Archives: 2017

Escudero CA1. Development of placental vascular tree is structurally and functionally required for both adequate placental growth and delivery of nutrients from mother to the fetus. Impaired placental angiogenesis has been implicated in the pathophysiology of pregnancy complications which have im...

Cumsille P1,2,3,4, Coronel A5,6, Conca C7,8, Quiñinao C9, Escudero C10,11,12. Abstract One of the main challenges in cancer modelling is to improve the knowledge of tumor progression in areas related to tumor growth, tumor-induced angiogenesis and targeted therapies efficacy. For this pur...

Veas C1, Jara C, Willis ND, Pérez-Contreras K, Gutierrez N, Toledo J, Fernandez P, Radojkovic C, Zuñiga FA, Escudero C, Aguayo C. Abstract Human endothelial progenitor cells (hEPC) are adult stem cells located in the bone marrow and peripheral blood. Studies have indicated that hEP...

Abstract Mesenchymal stem cells (MSCs) are adult multipotent stem cells that are able to differentiate into multiple specialized cell types including osteocytes, adipocytes, and chondrocytes. MSCs exert different functions in the body and have recently been predicted to have a major clinical/th...

Acurio J1, Herlitz K1, Troncoso F1, Aguayo C2,3, Bertoglia P4, Escudero C5,6. Abstract We aim to investigate whether A2A/nitric oxide-mediated regulation of vascular endothelial growth factor (VEGF) expression is impaired in feto-placental endothelial cells from late-onset pre-eclampsia...

Abstract HIGHLIGHTS Short-term incubation with insulin increases the L-arginine transport in HUVECs.Short-term incubation with insulin increases the NO synthesis in HUVECs.Insulin induces relaxation in human placental vascular bed.Insulin attenuates the constriction induced by hydrogen peroxid...

Cid M1, González M2. Abstract Changes in quality of nutrition, habits, and physical activity in modern societies increase susceptibility to obesity, which can deleteriously affect pregnancy outcome. In particular, a sedentary lifestyle causes dysfunction in blood flow, which impacts the card...

Dubó S1, Gallegos D2, Cabrera L3, Sobrevia L4, Zúñiga L5, González M6. Abstract Impairment of insulin signaling on diabetes mellitus has been related to cardiovascular dysfunction, heart failure, and sudden death. In human endothelium, cationic amino acid transporter 1 (hCAT-1) is r...

Sobrevia L1, Salsoso R2, Fuenzalida B3, Barros E3, Toledo L3, Silva L3, Pizarro C3, Subiabre M3, Villalobos R3, Araos J3, Toledo F4, González M5, Gutiérrez J6, Farías M3, Chiarello DI3, Pardo F3, Leiva A3. Abstract Gestational diabetes mellitus (GDM) is a disease of the mo...