Jaime Gutiérrez Pérez

• First degree (1999-2005): Biochemistry, Pontificia Universidad Católica de Chile, Chile.
• Postgraduate (2005-2007): Master degree, Biological Sciences, Pontificia Universidad Católica de Chile.
• Postgraduate (2005-2009): PhD (Cellular and Molecular Biology), Pontificia Universidad Católica de Chile, Chile.
• Postdoctoral (2009-2013): Laboratory of Cell Differentiation and Pathology (CRCP), Center of Aging and Regeneration (CARE). Department of Cell and Molecular Biology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.
• Postdoctoral (2010): Sprott Center Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada.
• Postdoctoral (2013-2014): Cellular and Molecular Physiology Laboratory (CMPL), Division of Obstetrics and Gynecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.

• CONICYT 79090027 (2009-2013): Responsible Researcher. (2010-01/2012-12). Proyecto de Inserción de capital humano avanzado en la academia. “Mejoramiento de la formación académica y científica en biología y fisiología celular: Función de células madres en regeneración tisular”. (Improving the academic and scientific training in biology and cell physiology: Role of stem cells in tissue regeneration) Pontificia Universidad Católica de Chile. Investigador Principal: Dr. Nibaldo Inestrosa.
• FONDECYT 11110010 (2011-2014): Principal Investigator (2011-10/2014-10) Reduced Reck levels improve the muscle cell therapy and diminish the fibrosis associated to the dystrophic muscle.
• FONDECYT 1150377 (2015-2018): Co-Investigator (2015-03/2018-03) Role of insulin receptors and adenosine receptors in prevention of fetoplacental endothelial dysfunction by insulin in women with gestational diabetes mellitus.
• USS 2015-0032-I (2016-2017): Principal Investigator. Proyecto Interno USS (2016-2017). Role of RECK in the development of human preeclampsia as regulator of cytotrophoblast invasiveness and endovascular differentiation.
• USS 2017 (2017-2018): Co-Investigator: Efecto de cotinina sobre la disfunción endotelial observada en embarazos que cursan con preeclamsia

Graduate:

•  David Gonzalez (PhD associated investigation units, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile.

Undergraduate:

• Nicolas Barrera (Professional thesis, Faculty of Health Sciences, Medical Technology, Universidad San Sebastian).
• Jacob Mora (Professional thesis, Faculty of Biological Sciences, Biochemistry, Universidad San Sebastian).
• Alejandro Aedo (Professional thesis, Faculty of Health Sciences, Medical Technology, Universidad San Sebastian).
• Marion Padilla (Professional thesis, Faculty of Health Sciences, Medical Technology, Universidad San Sebastian).
• Diego Figueroa (Professional thesis, Faculty of Health Sciences, Medical Technology, Universidad San Sebastian).
• Deyanira Seguel, (Professional thesis, Faculty of Health Sciences, Medical Technology, Universidad San Sebastian).
• Leila Fernandéz, (Professional thesis, Faculty of Health Sciences, Medical Technology, Universidad San Sebastian).
• Jorge Maldonado, (Professional thesis, Faculty of Health Sciences, Medical Technology, Universidad San Sebastian).
• Rodrígo Escalona, (Professional thesis, Faculty of Health Sciences, Medical Technology, Universidad San Sebastian).

1. Gutierrez, J., N. Osses, and E. Brandan, Changes in secreted and cell associated proteoglycan synthesis during conversion of myoblasts to osteoblasts in response to bone morphogenetic protein-2: role of decorin in cell response to BMP-2. J Cell Physiol, 2006. 206(1): p. 58-67.
2. Osses, N., J. Gutierrez, T. Lopez-Rovira, F. Ventura, and E. Brandan, Sulfation is required for bone morphogenetic protein 2-dependent Id1 induction. Biochem Biophys Res Commun, 2006. 344(4): p. 1207-15.
3. Droppelmann, C.A., J. Gutierrez, C. Vial, and E. Brandan, Matrix metalloproteinase-2-deficient fibroblasts exhibit an alteration in the fibrotic response to connective tissue growth factor/CCN2 because of an increase in the levels of endogenous fibronectin. J Biol Chem, 2009. 284(20): p. 13551-61.
4. Gutierrez, J. and E. Brandan, A novel mechanism of sequestering fibroblast growth factor 2 by glypican in lipid rafts, allowing skeletal muscle differentiation. Mol Cell Biol, 2010. 30(7): p. 1634-49.
5. Vial, C., J. Gutierrez, C. Santander, D. Cabrera, and E. Brandan, Decorin interacts with connective tissue growth factor (CTGF)/CCN2 by LRR12 inhibiting its biological activity. J Biol Chem, 2011. 286(27): p. 24242-52.
6. Calligaris, S.D., M. Lecanda, F. Solis, M. Ezquer, J. Gutierrez, E. Brandan, A. Leiva, L. Sobrevia, and P. Conget, Mice long-term high-fat diet feeding recapitulates human cardiovascular alterations: an animal model to study the early phases of diabetic cardiomyopathy. PLoS One, 2013. 8(4): p. e60931.
7. Brandan, E. and J. Gutierrez, Role of proteoglycans in the regulation of the skeletal muscle fibrotic response. FEBS J, 2013. 280(17): p. 4109-17.
8. Brandan, E. and J. Gutierrez, Role of skeletal muscle proteoglycans during myogenesis. Matrix Biol, 2013. 32(6): p. 289-97.
9. Morales, M.G., J. Gutierrez, C. Cabello-Verrugio, D. Cabrera, K.E. Lipson, R. Goldschmeding, and E. Brandan, Reducing CTGF/CCN2 slows down mdx muscle dystrophy and improves cell therapy. Hum Mol Genet, 2013. 22(24): p. 4938-51.
10. Gutierrez, J., D. Cabrera, and E. Brandan, Glypican-1 regulates myoblast response to HGF via Met in a lipid raft-dependent mechanism: effect on migration of skeletal muscle precursor cells. Skelet Muscle, 2014. 4(1): p. 5.
11. Cabrera, D., J. Gutierrez, C. Cabello-Verrugio, M.G. Morales, S. Mezzano, R. Fadic, J.C. Casar, J.L. Hancke, and E. Brandan, Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis. Skelet Muscle, 2014. 4: p. 6.
12. Pessina, P., D. Cabrera, M.G. Morales, C.A. Riquelme, J. Gutierrez, A.L. Serrano, E. Brandan, and P. Munoz-Canoves, Novel and optimized strategies for inducing fibrosis in vivo: focus on Duchenne Muscular Dystrophy. Skelet Muscle, 2014. 4: p. 7.
13. Pardo, F., L. Silva, T. Saez, R. Salsoso, J. Gutierrez, C. Sanhueza, A. Leiva, and L. Sobrevia, Human supraphysiological gestational weight gain and fetoplacental vascular dysfunction. Int J Obes (Lond), 2015. 39(8): p. 1264-73.
14. Ezquer, F., J. Gutierrez, M. Ezquer, C. Caglevic, H.C. Salgado, and S.D. Calligaris, Mesenchymal stem cell therapy for doxorubicin cardiomyopathy: hopes and fears. Stem Cell Res Ther, 2015. 6: p. 116.
15. Gutierrez, J., C.A. Droppelmann, O. Contreras, C. Takahashi, and E. Brandan, RECK-Mediated beta1-Integrin Regulation by TGF-beta1 Is Critical for Wound Contraction in Mice. PLoS One, 2015. 10(8): p. e0135005.
16. Leiva, A., B. Fuenzalida, F. Westermeier, F. Toledo, C. Salomon, J. Gutierrez, C. Sanhueza, F. Pardo, and L. Sobrevia, Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia. Oxid Med Cell Longev, 2015. 2015: p. 5346327.
17. Gutierrez, J., C.A. Droppelmann, R. Salsoso, F. Westermeier, F. Toledo, C. Salomon, C. Sanhueza, F. Pardo, A. Leiva, and L. Sobrevia, A Hypothesis for the Role of RECK in Angiogenesis. Curr Vasc Pharmacol, 2016. 14(1): p. 106-15.
18. Westermeier, F., T. Saez, P. Arroyo, F. Toledo, J. Gutierrez, C. Sanhueza, F. Pardo, A. Leiva, and L. Sobrevia, Insulin receptor isoforms: an integrated view focused on gestational diabetes mellitus. Diabetes Metab Res Rev, 2016. 32(4): p. 350-65.
19. Sanhueza, C., J. Araos, L. Naranjo, R. Villalobos, F. Westermeier, C. Salomon, A.R. Beltran, M.A. Ramirez, J. Gutierrez, F. Pardo, A. Leiva, and L. Sobrevia, Modulation of intracellular pH in human ovarian cancer. Curr Mol Med, 2016. 16(1): p. 23-32.
20. Leiva, A., B. Fuenzalida, R. Salsoso, E. Barros, F. Toledo, J. Gutierrez, F. Pardo, and L. Sobrevia, Tetrahydrobiopterin Role in human umbilical vein endothelial dysfunction in maternal supraphysiological hypercholesterolemia. Biochim Biophys Acta, 2016. 1862(4): p. 536-44.
21. Leiva, A., B. Fuenzalida, E. Barros, B. Sobrevia, R. Salsoso, T. Saez, R. Villalobos, L. Silva, I. Chiarello, F. Toledo, J. Gutierrez, C. Sanhueza, F. Pardo, and L. Sobrevia, Nitric Oxide is a Central Common Metabolite in Vascular Dysfunction Associated with Diseases of Human Pregnancy. Curr Vasc Pharmacol, 2016. 14(3): p. 237-59.
22. Sanhueza, C., J. Araos, L. Naranjo, E. Barros, L. Toledo, M. Subiabre, F. Toledo, J. Gutierrez, D.I. Chiarello, F. Pardo, A. Leiva, and L. Sobrevia, Are NHE1 and inducible nitric oxide synthase involved in human ovarian cancer? Pharmacol Res, 2016. 105: p. 183-5.
23. Sobrevia, L., R. Salsoso, B. Fuenzalida, E. Barros, L. Toledo, L. Silva, C. Pizarro, M. Subiabre, R. Villalobos, J. Araos, F. Toledo, M. Gonzalez, J. Gutierrez, M. Farias, D.I. Chiarello, F. Pardo, and A. Leiva, Insulin Is a Key Modulator of Fetoplacental Endothelium Metabolic Disturbances in Gestational Diabetes Mellitus. Front Physiol, 2016. 7: p. 119.
24. Araos, J., Silva, L., Salsoso, R., Saez, T., Barros, E., Toledo, F., Gutierrez, J., Pardo, F., Leiva, A., Sanhueza, C., Sobrevia, L.*, Intracellular and extracellular pH dynamics in the human placenta from diabetes mellitus. Placenta 2016. 43: 47-53.
25. Carlos Sanhueza*, Joaquín Araos, Luciano Naranjo, Eric Barros, Lilian Toledo, Mario Subiabre, Fernando Toledo, Jaime Gutiérrez, Fabián Pardo, Andrea Leiva, Luis Sobrevia*. Nitric oxide and pH modulation in gynaecological cancer. J Cell Mol Med. 2016 Jul 29.
26. Carlos Sanhueza, Joaquín Araos, Luciano Naranjo, Fernando Toledo, Ana R Beltrán, Marco A Ramírez, Jaime Gutiérrez, Fabián Pardo, Andrea Leiva and Luis Sobrevia*. Sodium/proton Exchanger Isoform 1 Regulates Intracellular pH and Cell Proliferation in Human Ovarian Cancer. Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease 2017 1863 (1): 81-91.
27. Salsoso, R., Gutierrez, J., Farias, M., Pardo, F., Chiarello, D., Leiva, A., Toledo, F., Sobrevia, L. (2016) Adenosine and preeclampsia. Molecular Aspects of Medicine. 2017 55: p 126-139.
28. Leiva, A., E. Guzman-Gutierrez, S. Contreras-Duarte, B. Fuenzalida, C. Cantin, L. Carvajal, R. Salsoso, J. Gutierrez, F. Pardo, and L. Sobrevia, Adenosine receptors: Modulators of lipid availability that are controlled by lipid levels. Mol Aspects Med, 2017. 2017 55: p. 26-44
29. Pardo, F., R. Villalobos-Labra, D.I. Chiarello, R. Salsoso, F. Toledo, J. Gutierrez, A. Leiva, and L. Sobrevia, Molecular implications of adenosine in obesity. Mol Aspects Med, 2017 55: p90-101.
30. Jayabalan, N., S. Nair, Z. Nuzhat, G.E. Rice, F.A. Zuniga, L. Sobrevia, A. Leiva, C. Sanhueza, J.A. Gutierrez, M. Lappas, D.J. Freeman, and C. Salomon, Cross Talk between Adipose Tissue and Placenta in Obese and Gestational Diabetes Mellitus Pregnancies via Exosomes. Front Endocrinol (Lausanne), 2017. 8: p. 239.
31. Gutierrez, J., A. Aedo, J. Mora, J. Maldonado, R. Salsoso, F. Toledo, M. Farias, F. Pardo, A. Leiva, and L. Sobrevia, Preeclampsia associates with RECK-dependent decrease in human trophoblasts migration and invasion. Placenta, 2017. 59: p. 19-29.
32. Quezada, C.*, Torres, A., Niechi, I., Uribe, D., Contreras-Duarte, S., Toledo, F., San Martín, R., Gutiérrez, J.*, Sobrevia, L.*, Role of extracellular vesicles in glioma progression. Molecular Aspects of Medicine. In Press 2018.