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cescudero@ubiobio.cl

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+56 42 2463079

Dra. Ambart Covarrubias

GRIVAS   →  Researchers   →  Dra. Ambart Covarrubias

Dra. Ambart Covarrubias

Info

Academic Degrees

  • First degree (2003-2007): Medical Technologist. University of Valparaiso, Chile.
  • Postgraduate (2005-2009): PhD (Cell and Tissue Biology), University of Sao Paulo, Brazil.
  • Postdoctoral (2017 – 2018): Karumanchi Laboratory, Center of Vascular Biology Research, Renal Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA.
  • Postdoctoral (2018 – present): Karumanchi Laboratory, Renovascular Research, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles. USA

Research Grant

  • CONICYT 74170038 (2017-1018) Scholarship: Becas Chile de Postdoctorado.
  • USS 2017 (2017-2018): Efecto de cotinina sobre la la disfunción endotelial observada en embarazos que cursan con preeclamsia. Co-Investigator.
  • FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo), (01/02/2014 to 31/01/2016). Effect of ovarian hormones on the expression and synthesis of extracellular matrix molecules in deciuduales cells. Host institution: University of São Paulo, Process 2013/ 16922-4. Research-Regular FAPESP. Research associate.
  • FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo), (01/04/2012 to 31/03/2014). Assessing the impact of type 1 diabetes on uterine responsiveness to stimulation by estrogen tissues. Process 11 / 22429-3. Research- Regular FAPESP. Research associate.
  • CONICYT 2608130. (2009-2013) Scholarship: Becas Gestion Propia Doctorado.

Student supervisor

  • Madeline Foitzick. Professional thesis, Faculty of Health Sciences, Medical Technology, Universidad San Sebastian. Co-adviser
  • Anthony Home Poblete. Professional thesis, Faculty of Health Sciences, Medical Technology, Universidad San Sebastian. Adviser
  • Jose Altamirano. Professional thesis, Faculty of Health Sciences, Medical Technology, Universidad San Sebastian. Adviser
  • Nicole Saavedra Rodriguez. Professional thesis, Faculty of Health Sciences, Medical Technology, Universidad San Sebastian. Adviser
  • Cecilia Cid. Professional thesis, Faculty of Health Sciences, Medical Technology, Universidad San Sebastian. Adviser
  • Fernanda Ceballos. Professional thesis, Faculty of Health Sciences, Medical Technology, Universidad San Sebastian. Adviser

Publications

  1. Phagocytosis of Leptospira by leukocytes from mice with different susceptibility to leptospirosis and possible role of chemokines. Silva PLD, Lauretti-Ferreira F, Caldas de Lima M, Lima SS, Covarrubias AE, De Franco M, Carvalho E, Ho PL, da Costa RMA, Martins EAL, Da Silva JB. BMC Microbiol. 2019 Jan 7;19(1):4. doi: 10.1186/s12866-018-1371-9. PMID:30616505.
  2. AP39, a modulator of mitochondrial bioenergetics, reduces anti-angiogenic response and oxidative stress in hypoxia-exposed trophoblasts: relevance for preeclampsia pathogenesis. Covarrubias AE, Lecarpentier E, Lo A, Salahuddin S, Gray KJ, Karumanchi SA, Zsengellér ZK. Am J Pathol.2019 Jan;189(1):104-114. doi: 10.1016/j.ajpath.2018.09.007. Epub 2018 Oct 11. P ID: 30315766
  3. The absence of the embryo in the pseudopregnant uterus alters the deposition of some ECM molecules during decidualization in mice. Covarrubias AE, Barrence FC, Zorn TM. Connect Tissue Res. 2015 Jun;56(3):253-63. doi: 10.3109/03008207.2015.1023432. Epub 2015 Mar 31. PMID:25738597.
  4. Endothelium trans differentiated from Wharton’s jelly mesenchymal cells promote tissue regeneration: potential role of soluble pro-angiogenic factors. Aguilera V, Briceño L, Contreras H, Lamperti L, Sepúlveda E, Díaz-Perez F, León M, Veas C, Maura R, Toledo JR, Fernández P, Covarrubias A, Zuñiga FA, Radojkovic C, Escudero C, Aguayo C. PLoS One. 2014 Nov 20;9(11):e111025. doi: 10.1371/journal.pone.0111025. eCollection 2014. PMID:25412260.
  5. Long-term type 1 diabetes impairs decidualization and extracellular matrix remodeling during early embryonic development in mice. Favaro RR, Salgado RM, Covarrubias AC, Bruni F, Lima C, Fortes ZB, Zorn TM. Placenta. 2013 Dec;34(12):1128-35. doi: 10.1016/j.placenta.2013.09.012. Epub 2013 Sep 30. PMID:24125804.
  6. Estradiol induces transcriptional and posttranscriptional modifications in versican expression in the mouse uterus. Salgado RM, Covarrubias AC, Favaro RR, Serrano-Nascimento C, Nunes MT, Zorn TM. J Mol Histol. 2013 Apr;44(2):221-9. doi: 10.1007/s10735-012-9476-1. Epub 2012 Dec 28. PMID: 23271141.
  7. Induction of TNF-alfa and CXCL-2 mRNAs in different organs of mice infected with pathogenic Leptospira. da Silva JB, Carvalho E, Covarrubias AE, Ching AT, Mattaraia VG, Paiva D, de Franco M, Fávaro RD, Pereira MM, Vasconcellos S, Zorn TT, Ho PL, Martins EA. Microb Pathog. 2012 Apr;52(4):206-16. doi: 10.1016/j.micpath.2012.01.002. Epub 2012 Feb 8. PMID: 22342618.
  8. Double disruption of α2A- and α2C-adrenoceptors results in sympathetic hyperactivity and high-bone-mass phenotype. Fonseca TL, Jorgetti V, Costa CC, Capelo LP, Covarrubias AE, Moulatlet AC, Teixeira MB, Hesse E, Morethson P, Beber EH, Freitas FR, Wang CC, Nonaka KO, Oliveira R, Casarini DE, Zorn TM, Brum PC, Gouveia CH. J Bone Miner Res. 2011 Mar;26(3):591-603. doi: 10.1002/jbmr.243. PMID: 20814988.