Claudio Aguayo

Dr. Claudio Aguayo Tapia, MsC PhD Group of Vascular Functions (GIFE) Assistant Professor Clinical Biochemistry and Immunology Department Faculty of Pharmacy Universidad de Concepción Concepción, Chile Phone: 56-41-2207196 Mobil: 56-9-96099232

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  • Dr. Claudio Aguayo Tapia, MsC PhD
  • Group of Vascular Functions (GIFE)
  • Assistant Professor
  • Clinical Biochemistry and Immunology Department
  • Faculty of Pharmacy
  • Universidad de Concepción
  • Concepción, Chile
  • Phone: 56-41-2207196
  • Mobil: 56-9-96099232

Ongoing grants

  • PI. DI-UDEC GI/EF. March 2011-2013 (USD $ 10K)
  • PI. INNOVA CORFO 12IDL2-13351. March 2012-2015 (USD $ 240K)
  • Co-Investigator, MECESUP Convenio desempeño UDEC UCO1201. March 2013-2015. (USD $ 2.400K)
  • Co-Investigator, DI-UDEC GI/EF. March 2011-2013 (USD $ 10K)

Finished grants

  • PI. DI-UDEC GI/EF. March 2011-2013 (USD $ 10K).
  • PI. FONDECYT. November 2007-2010. (USD $ 120K)
  • Co-investigador. DI-UDEC GI/EF. March 2009-2011 (USD $ 10K)
  • Co-investigador. DI-UDEC GI/EF. March 2009-2010 (USD $ 10K)
  • Co-Investigator, INNOVA Chile 1BCN2005S-196. March 2008-2010 (USD $ 1.000K)
  • PI. DI-UDEC GI/EF. March 2005-2007 (USD $ 10K)
  • Co-investigador. DI-UDEC GI/EF. March 2006-2008 (USD $ 10K)

Honorary mentions

 

  • Best presentation in Young Physiologist’s Symposium: Advances in Cell and Molecular Physiology (Pucón, Noviembre 1999). The Physiological Society UK and Chilean Physiological Society
  • Best Presentation in XIII Congreso Chileno de Química Clínica, Termas de Chillan, Chile 2003.
  • Full Member of The Sociedad Chilena de Ciencias Fisiológicas (SCHCF).
  • Full Member of The Grupo Latinoamericano para el Estudio de la Biología Molecular en Diabetes (GLEBIMOD).

Visiting Research

  

  • Chile: Placental Laboratory, Department of Nephrology; Cellular and Molecular Physiology Laboratory (CMPL), Department of Obstetric and Gynecology, Medicine Faculty, Pontificia Universidad Católica de Chile.
  • UK: Inglaterra Center for Cardiovascular Biology and Medicine, University of London, England. Julio-Agosto 2000.
  • Spain:  Universitat de Barcelona, Facultat de Biología, Departament de Bioquímica I Biología Molecular; Barcelona, 2001 & 2002; Laboratorio de Fisiopatología Cardiovascular Molecular y Genética, Dpto. Aterotrombosis e Imagen Cardiovascular. Unidad de proteomica, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 2009.

Speaker at International Meetings in:

  

  • UK, Spain, Chile, Uruguay, Argentina, Venezuela & Cuba.

Publications

  

(*Corresponding Author)

  1. Lemon grass (Cymbopogon citratus (D.C) Stapf) polyphenols protect human umbilical vein endothelial cell (HUVECs) from oxidative damage induced by high glucose, hydrogen peroxide and oxidised low-density lipoprotein. J. Campos, G. Schmeda-Hirschmann, E. Leiva, L. Guzmán, R. Orrego, P. Fernández, M. González, C. Radojkovic, F.A. Zuñiga, L. Lamperti, E. Pasten & C. Aguayo*. For publication in Food Chemistry, 2014.
  2. Escudero A, Petzold G, Moreno J, Gonzalez M, Junod J, Aguayo C, Acurio J, Escudero C*. Supplementation with apple enriched with L-arginine may improve metabolic control and survival rate in alloxan-induced diabetic rats. Biofactors. 2013 Sep;39(5):564-74.
  3. Escudero C*, Bertoglia P, Hernández M, Celis C, Marcelo G, Aguayo C & Acurio J. Impaired A2A adenosine receptor/nitric oxide/ VEGF signaling pathway in fetal endothelium during late and early-onset pre-eclampsia. Purinergic Signal. 2013 Jun;9(2):215-26.
  4. Escudero A, Carreño B, Retamal N, Celis C, Castro L, Aguayo C, Acurio J, Escudero C*. Elevated concentrations of plasma adenosine in obese children. Biofactors. 2012 38(6):422-8.
  5. Díaz-Pérez F, Radojkovic C, Aguilera V, Veas C, González M, Lamperti L, Escudero C, Aguayo C.*  L-arginine transport and nitric oxide synthesis in human endothelial progenitor cells. J Cardiovasc Pharmacol. 2012 60(5):439-49.
  6. Orellana G, Sapunar S, Sáez K, Aguayo C, Calvo C, Radojkovic C, Riffo B, Gleisner A, Asenjo S & Ulloa N.* Asociación entre polimorfismos del gen de adiponectina y estado nutricional en escolares de la comuna de Hualpén. Rev Med Chile 2012; 140: 1245-1252.
  7. Fernández P, Jara C, Aguilera V, Caviedes L, Díaz F, Radojkovic C, Veas C, Lamperti L, Escudero C, Aguayo C.* Adenosine A2A and A2 receptors are involved in the human endothelial progenitor cells migration. J Cardiovasc Pharmacol. 2012 May;59(5):397-404.
  8. Riffo B, Asenjo S, Sáez K, Aguayo C, Muñoz I, Bustos P, Celis-Morales C, Lagos J, Sapunar J, Ulloa N.* FTO gene is related to obesity in Chilean Amerindian children and impairs HOMA-IR in prepubertal girls. Pediatr Diabetes. 2012 Aug;13(5):384-91.
  9. Veas CJ, Aguilera VC, Muñoz IJ, Gallardo VI, Miguel PL, González MA, Lamperti LI, Escudero CA, Aguayo CR.* Fetal endothelium dysfunction is associated with circulating maternal levels of sE-selectin, sVCAM1, and sFlt-1 during pre-eclampsia. J Matern Fetal Neonatal Med. 2011 Nov;24(11):1371-7.
  10. Searle A, Gómez-Rosso L, Meroño T, Salomón C, Durán-Sandoval D, Giunta G, Grant C, Calvo C, Lamperti L, Brites F, Aguayo C.*  High LDL levels are associated with increased lipoprotein-associated phospholipase A(2) activity on nitric oxide synthesis and reactive oxygen species formation in human endothelial cells. Clin Biochem. 2011 Feb;44(2-3):171-7.
  11. Guzmán-Gutiérrez E, Sandoval C, Nova E, Castillo JL, Vera JC, Lamperti L, Krause B, Salomón C, Sepúlveda C, Aguayo C, Sobrevia L.* Differential expression of functional nucleoside transporters in non-differentiated and differentiated human endothelial progenitor cells. Placenta. 2010 Oct;31(10):928-36.
  12. Puebla C, Farías M, González M, Vecchiola A, Aguayo C, Krause B, Pastor-Anglada M, Casanello P, Sobrevia L.* High D-glucose reduces SLC29A1 promoter activity and adenosine transport involving specific protein 1 in human umbilical vein endothelium. J Cell Physiol. 2008 Jun;215(3):645-56.
  13. Aguayo, C., Casado, J., González, M., Pearson, J.D., San Martín, R., Casanello, P., Pastor-Anglada, M. & Sobrevia, L.* Equilibrative nucleoside transporter 2 is expressed in human umbilical vein endothelium, but is not involved in the inhibition of adenosine transport induced by hyperglycaemia. Placenta. 26:641-53, 2005.
  14. Flores, C., Rojas, S., Aguayo, C., Parodi, J., Mann, G., Pearson, J.D., Casanello, P. & Sobrevia, L.* Rapid stimulation of L-arginine transport by D-glucose involves p42/44(mapk) and nitric oxide in human umbilical vein endothelium. Circulation Research 92:64-72, 2003.
  15. Parodi, J., Flores, C., Aguayo, C., Rudolph, M.I., Casanello, P. & Sobrevia, L.*  Inhibition of nitrobenzylthioinosine-sensitive adenosine transport by elevated D-glucose involves activation of P2Y2 purinoceptors in human umbilical vein endothelial cells.  Circulation Research 90:570-577, 2002.
  16. Aguayo, C., Flores, C., Parodi, J., Rojas, R., Mann, G.E. Pearson, J.D. & Sobrevia, L.*  Modulation of adenosine transport by insulin in human umbilical artery smooth muscle cells from normal or gestational diabetic pregnancies. Journal of Physiology 534, 243- 254, 2001.
  17. Aguayo, C. & Sobrevia, L.* Nitric oxide, cGMP , and cAMP regulate adenosine transport in human umbilical artery smooth muscle cells from gestational diabetes.  Experimental Physiology 85:399-409, 2000.
  18. 18.  Montecinos, V.P., Aguayo, C., Flores, C., Wyatt, A., Pearson, J.D., Mann, G.E. & Sobrevia, L.* Regulation of adenosine transport by D-glucose in human fetal endothelial cells: Involvement of nitric oxide, protein kinase C and mitogen-activated protein kinase. Journal of Physiology 529: 777-790, 2000.