Carlos Escudero

Carlos Escudero, MD PhD Vascular Physiology Laboratory, Group of Tumor Angiogenesis (GIANT) Group of Research and Innovation in Vascular Health (GRIVAS Health) Associated Professor Basic Sciences Department Faculty of Sciences […]

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  • Carlos Escudero, MD PhD
  • Vascular Physiology Laboratory,
  • Group of Tumor Angiogenesis (GIANT)
  • Group of Research and Innovation in Vascular Health (GRIVAS Health)
  • Associated Professor
  • Basic Sciences Department
  • Faculty of Sciences
  • Universidad del Bio-Bio
  • Chillán, Chile
  • Phone: 56-42-463256
  • Mobil: 56-9-65655127

Ongoing grants

  • PI. DIUBB 122109 GI/EF. March 2012-2014 (USD $ 10K)
  • PI. Conicyt 79112027. March 2012-2015 (USD $ 120K)
  • PI. FONDECYT Regular 1100684, March 2010-2014. (USD $ 400K)
  • Co-Investigator, CONICYT-Anillo. March 2010-2013. (USD $ 1.500K)

Finished grants

  • PI. PEUC-05-2013. May-April 2013.
  • PI. Universidad del Bio Bio. Direccion de postgrado. May 2011-2012.
  • PI. Direction of Research Grants. Universidad del Bio Bio. 096509 1/RS. August 2009- 2010.
  • PI. CONICYT 24071039, Comisión Nacional de Investigación Científica y Tecnológica  (CONICYT) from Chile. Since October 2007-2009.
  • PI. CONICYT Research visit grant, March to June, 2008.
  • VRAID-PUC 2008 International Congress Attendance (08/2008)
  • PUC-MECESUP Research visit grant.  Pontificia Universidad Católica and Chilean Ministry of Education, Programa de Mejoramiento de la Calidad y Equidad de la Educación Superior (MECESUP). August to October 2007.
  • CONICYT International Congress Attendance (08/2007).
  • NIH-USA International Congress Attendance (08/2007)
  • MECESUP and PUC, PhD Scholarship. Since March 2005-2009.
  • Co-investigador VRAID-BM16 (2007-2008)
  • Co-investigador FUNDACYT PFN-03-053 (2003-2004).
  • Co-investigador Sustainable Science Institute – Public Health School of Berkeley (2001-2002).

Honorary mentions

  • Chair of the ECR at the International Federation of Placental Association October 2010-2012.
  • Young Investigator (Travel Award). Dr. YW Loke, IFPA 2009, 2011.
  • Member of the “International Federation of Placental Association New Investigator Committee”. March 2009-2010.
  • Member of the “New Investigator Advisory Group” SGI 2010.
  • Young Investigator (Travel Award). ISSHP2008
  • Honorific mention for the poster presented at Aspen Perinatal Biology Symposium, National Institute of Health, USA.
  • Honorific mention for the poster presented at IFPA2007 meeting. Dr. YW Loke and National Institute of Health, USA.
  • Full Member of The Sociedad Chilena de Ciencias Fisiológicas (SCHCF).
  • Vicepresident, National Association of Rural Physician from Ecuador (ANAMER).

Visiting Research

  • Chile: Placental Laboratory, Department of Nephrology; Cellular and Molecular Physiology Laboratory (CMPL), Department of Obstetric and Gynecology, Medicine Faculty, Pontificia Universidad Católica de Chile.
  • Italy:  Institute of Biochemistry-University of Ancona. International Coenzyme Q10 Association.
  • USA: International Public Health Summer Institute, John J Sparkamn Center for International Public Health Education, School of Public Health, University of Alabama at Birmingham, Alabama, USA; Department of Obstetric and Gynecology. University of Cincinnati, Cincinnati, Magee-Womens Research Institute.

Speaker at International Meetings in:

  • Australia, Bolivia, Canada, Colombia, Chile, Ecuador, Geneva, United Stated of America, Venezuela, Japan.

Publications

 (*Corresponding Author)

  1. Escudero A, Petzold G, Moreno J, Gonzalez M, Junod J, Aguayo C, Acurio J, Escudero C*. Supplementation with apple enriched with L-arginine may improve metabolic control and survival rate in alloxan-induced diabetic rats. Biofactors. 2013;39(5):564-74.
  2. Escudero C*, Bertoglia P, Munoz F, Roberts JM. Purinas y acido urico en pre-eclampsia: interacciones fisiopatologicas y proyecciones en investigacion. Revista Medica de Chile. 2013;141:895-902
  3. Escudero C*, Bertoglia P, Hernandez M, Celis C, Gonzalez M, Aguayo C, Acurio J. Impaired A2A adenosine receptor/nitric oxide/ VEGF signaling pathway in fetal endothelium during late and early-onset pre-eclampsia. Purinergic Signalling. 2013;9(2):215-226.
  4. Escudero A, Carreno B, Retamal N, Castro L, Aguayo C, Acurio J, Escudero C*. Elevated adenosine plasma levels in obese children. Biofactors. 2012;38(6):422-8. doi: 10.1002/biof.1039.
  5. Diaz-Perez F, Radojkovic C, Aguiler V, Veas C, Gonzalez M, Lamperti L, Escudero C*, Aguayo C*. L-arginine transport and nitric oxide synthesis in human endothelial progenitor cells. Journal of Cardiovascular Pharmacology. 2012;60(5):439-449.
  6. Oyarzo C, Bertoglia P, Avendano R, Bacigalupo F, Escudero A, Acurio J, Escudero C*. Adverse perinatal outcomes after the February 27th 2010 Chilean earthquake. Journal of Maternal-Fetal and Neonatal Medicine. 2012 Oct;25(10):1868-73.
  7. Escudero C*, Sobrevia L. Adenosine plasma levels in the feto-placental circulation in pre-eclampsia. American Journal Obstetric and Gynaecology. 2012;206(4):e5-6.
  8. Fernandez P, Jara C, Aguilera V, Caviedes L, Diaz F, Radojkovic C, Veas C, Lamperti L, Escudero C*, Aguayo C*. Adenosine A2A and A3 receptors are involved in the human endothelial progenitor cells migration. Journal of Cardiovascular Pharmacology 2012;59(5):397-404.
  9. Roberts JM*, Escudero C. The placenta in pre-eclampsia. Pregnancy Hypertension. 2012 2(2) pp72-83.
  10. Abad C, Antczak DF, Carvalho J, Chamley LW, Chen Q, Daher S, Damiano AE, Dantzer V, Díaz P, Dunk CE, Daly E, Escudero C, Falcón B, Guillomot M, Han YW, Harris LK, Huidobro-Toro JP, Illsley N, Jammes H, Jansson T, Johnson GA, Kfoury JR Jr, Marín R, Murthi P, Novakovic B, Myatt L, Petroff MG, Pereira FT, Pfarrer C, Redman CW, Rice G, Saffery R, Tolosa JM, Vaillancourt C, Wareing M, Yuen R, Lash GE*. IFPA Meeting 2010 Workshop Report I: Immunology; Ion transport; Epigenetics; Vascular reactivity; Epitheliochorial placentation; Proteomics. Placenta. 2011;32(Suppl 2):S81-9.
  11. Veas CJ, Muñoz IJ, Gallardo VI, Miguel PL, González MA, Lamperti LA, Escudero C*, Aguayo C*. Umbilical vein endothelium activation is associated with high maternal circulating levels of E-selectin, VCAM-1 and sFlt-1 during severe pre-eclampsia. Journal of Maternal-Fetal and Neonatal Medicine. 2011;24(11):1371-7.
  12. Bertoglia P, Rivas A, Navarrete P, Castro L, Acurio J, Escudero C*. Resultados clínicos y perinatales de los embarazos con hipertensión arterial en un hospital de referencia de la VIII región de Chile. Revista Chilena de Obstetricia y Ginecología. 2010;75(3):162-171.
  13. Roa H, Gajardo C, Troncoso E, Fuentealba V, Escudero C, Yáñez A, Sobrevia L, Pastor-Anglada M, Quezada C, San Martin R*. Adenosine mediates transforming growth factor-beta 1 release in kidney glomeruli of diabetic rats. FEBS Lett 2009;583(19):3192-8.
  14. Casanello P*, Krause B, Torres E, Gallardo V, González M, Prieto C, Escudero C, Farías M, Sobrevia L. Reduced l-arginine transport and nitric oxide synthesis in human umbilical vein endothelial cells from intrauterine growth restriction pregnancies is not further altered by hypoxia. Placenta. 2009;30(7):625-33.
  15. Escudero C*, Puebla C, Westermeier F, Sobrevia L. Potential cell signaling mechanisms involved in the differential placental angiogenesis in mild and severe pre-eclampsia. Current Vascular Pharmacology. 2009;7(4):475-85.
  16. Westermeier F, Puebla C, Vega JL, Farias M, Escudero C, Casanello P, Sobrevia L*. Equilibrative Nucleoside Transporters in Fetal Endothelial Dysfunction in Diabetes mellitus and Hyperglycaemia. Current Vascular Pharmacology. 2009;7(4):435-49.
  17. Escudero C, Casanello P, Sobrevia L*. Human equilibrative nucleoside transporters 1 and 2 may be differentially modulated by A2B adenosine receptors in placenta microvascular endothelial cells from pre-eclampsia. Placenta. 2008;29(9):816-825.
  18. Escudero C, Sobrevia L*. A hypothesis for pre-eclampsia: Adenosine and inducible nitric oxide synthase in human placental microvascular endothelium. Placenta. 2008;29(6):469-483.
  19. Terán E*, Calle A, Escudero C. Endothelial dysfunction and pre-eclampsia. American Journal of Hypertension. 2007;20(9):1026-1027.
  20. Escudero C, Casanello P, Sobrevia L*. Disminución del flujo placentario en pre-eclampsia severa: ¿está involucrada adenosina en éste fenómeno? Boletín Sociedad Española de Ciencias Fisiológicas. 2007;9(1):6-9.
  21. Casanello P*, Escudero C, Sobrevia L. Equilibrative Nucleoside (ENTs) and Cationic Amino acid (CATs) Transporters: Implications in Foetal Endothelial Dysfunction in Human Pregnancy Diseases. Current Vascular Pharmacology. 2007;5(1):69-84.
  22. Escudero C*,  Calle A. Hierro, oxígeno y desarrollo placentario en la génesis de la pre-eclampsia: Efectos de la altura en Ecuador. Revista Médica de Chile 2006; 134(4): 491-498.
  23. Terán E*, Escudero C, Vivero S, Moya W, Calle A. Abnormal release of nitric oxide from nitrosoprotein in pre-eclampsia. International Journal of Gynecology & Obstetric. 2006;92(3):260-1.
  24. Terán E*, Escudero C, Vivero S, Calle A, Molina G. NO in Early Pregnancy and Development of Pre-eclampsia. Hypertension. 2006;47(4):e17
  25. Terán E*, Escudero C, Calle A. C-reactive protein levels during normal pregnancy and pre-eclampsia. International Journal of Gynecology & Obstetric. 2005;89(3):299-300.
  26. Terán E*, Escudero C, Vivero S, Enriquez A, Calle A. Intraplatelet levels of cGMP during normal pregnancy and pre-eclampsia. Hypertension in Pregnancy. 2004;23(3):303-308.
  27. Terán E*, Escudero C, Vivero S, Racines-Robe M, Mora L, Jerome P, Moya W, Molina G, Calle A. La mitocondria y la coenzima Q10 en la patogénesis de la pre-eclampsia. Revista Ecuatoriana de Ginecología y Obstetricia. 2004;12:122-125.
  28. Navarre A, Nicolalde V, Nieto B, Escudero C*. Pre-eclampsia y comportamiento sexual. Actualidad. 2003;14(1):34-39.
  29. Terán E*, Escudero C, Calle A. Seroprevalence of antibodies of Chlamydia Pneumoniae, Helicobacter Pylori and Streptolysine O as a risk factor to develop  pre-eclampsia. Obstetric and Gynecology. 2003;102(1):198-199.
  30. Terán E*, Racines M, Vivero S, Escudero C, Molina G, Calle A. Pre-eclampsia is associated with a decrease in plasma coenzyme Q10 levels. Free Radicals Biology and Medicine. 2003;35(11):1453-1456.
  31. Terán E*, Escudero C, Vivero S. Physiological change in platelet aggregation and nitric oxide levels during menstrual cycle in healthy women. Nitric Oxide. 2002;7(3):217-220.
  32. Terán E*, Hernandez I, Escudero C, Vivero S, Racines M: Aspects molecular de la disfunción eréctil y su tratamiento actual.  Urología Panamericana 2002:14(2):42-46.
  33. Escudero C*, Delgado C, Echeverria P, Cervantes C, Rojas P, Nájera E, Terán E. El adipocito como pieza fundamental en la disfunción endotelial de la obesidad. Metrociencia. 2001, 10(2):5-9.
  34. Terán E, Escudero C, Moya W, Flores M, Vallance P, Lopez-Jaramillo P*: Elevated C-reactive protein and pro-inflammatory cytoquines in Andean women with pre-eclampsia. International Journal of Gynecology & Obstetrics. 2001;75(3):243-249.
  35. Escudero C, Pasquel M, Terán E*. El proceso inflamatorio y las enfermedades cardiovasculares: Papel de la proteína C reactiva. Revista Ecuatoriana de Cardiología. 2000;IX (4): 161-167.
  36. Terán E*, Escudero C, Hernandez I, Vivero S, Racines M. Función Plaquetaria durante el embarazo normal y la pre-eclampsia. Revista Ecuatoriana de Ginecología y Obstetricia. 2000;7(3):274-277.
  37. López-Jaramillo P*,  Accini JL,  Felix C,  Sotomayor A, Escudero C. Evaluación de estudios clínicos de recuperación de la función endotelial con fármacos hipotensores. Revista  Colombiana de Cardiología. 1999;7(3):133-148.
  38. López-Jaramillo P*, Ruano C, Félix C, Escudero C. Factores de riesgo emergentes para enfermedad cardiovascular. Metrociencia. 1998;7(2):5-15.
  39. López-Jaramillo P*, Escudero C, Rivera J, Flores M, de Félix M, Barba L, Villacrés M. Las enfermedades cardiovasculares en los países subdesarrollados: La epidemia del fin del siglo. Medicas UIS (Colombia).1999;13:34-39.
  40. López-Jaramillo P*, Terán E, de Félix M, Villacrés M, Barba L, Escudero C. Efectos de la terapia estrogénica sustitutiva sobre la actividad de las sintasas de óxido nítrico. Endocrinología (España). 1998;45:205-208.
  41. López-Jaramillo P*, Terán E, Escudero C, Rivera J, Flores M, Ruano C. Papel de los radicales libres en la génesis de las enfermedades cardiovasculares. Revista Ecuatoriana de Cardiología. 1998;6:4-11.
  42. Lopez-Jaramillo P*, Felix C, Escudero C, López M. Factores de riesgo clásicos y emergentes para enfermedad cardiovascular. MEDUNAB. 1998;3(1):171-183.
  43. López-Jaramillo P*, Escudero C, Yumiceba I, Páez J. La arginina redescubierta: Su papel en la prevención de la aterosclerosis. Endocrinología Bolivariana. 1997;6:21-27.

Book Chaptersh

  • Escudero C*, Gonzalez M, Acurio J, Valenzuela F, Sobrevia L. The role of placenta in the fetal programming associated to gestational diabetes (2013). In Gestational Diabetes – Causes, Diagnosis and Treatment. Eds. Sobrevia L. Ed. InTech. In press.
  •  Sobrevia L*, Guzmán-Gutiérrez E, Westermeier F, Salomón C, Arroyo P, Palacios E, Bugueño K, Santos M, Diez de Medina C, González M, Escudero C, Mate A, Vásquez CM, Pardo F, Leiva A (2012). Fetoplacental Vascular Pathophysiology In Preeclampsia. In: Recent Research Developments in Physiology. Eds. Pandalai. Ed. Research Signpost, India. Chapter 7, pg 105-158.
  •  Escudero C*, Sobrevia L. (2009) Understanding high extracellular adenosine level in fetal-placental circulation during preeclamptic pregnancies. In: Membrane Transporters and Receptors in Disease. Eds. L Sobrevia, P Casanello. Ed. Research Signpost, India. Chapter 2, pg 27-53.