Andrés Rodríguez

Andrés I. Rodríguez Morales, Bq PhD Vascular Physiology Laboratory, Group of Tumor Angiogenesis (GIANT) Group of Research and Innovation in Vascular Health (GRIVAS Health) Assistant Professor Basic Sciences Department Faculty […]

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  • Andrés I. Rodríguez Morales, Bq PhD
  • Vascular Physiology Laboratory,
  • Group of Tumor Angiogenesis (GIANT)
  • Group of Research and Innovation in Vascular Health (GRIVAS Health)
  • Assistant Professor
  • Basic Sciences Department
  • Faculty of Sciences
  • Universidad del Bio-Bio
  • Chillán, Chile
  • Phone: 56-42-463356
  • Mobil: 56-9-942462107

Ongoing grants

  • P.I. UBB-DIUBB 180709 3/R Efecto de estrés de roce en células de melanoma, como agente modificador del microambiente vascular. 2018-2019 (USD $10k)
  • C.I. UBB- GI153109/EF. Grupo de Investigación de Angiogenesis Tumoral (en vías de consolidación) 2017-2019  (USD $20k)

Finished grants

  • P.I . UBB – DIUBB 166709 3/R Efecto del Receptor A2A de Adenosina en crecimiento y flujo sanguíneo tumoral. 2016-2017.
  • C.I. UBB – GI153109/EF. Grupo de Investigación de Angiogenesis Tumoral (en vías de consolidación). 2015-2019.
  • P.I. FAPESP – 2013/06241-0 Interaction between RhoGDI and PDI chaperones in rac1-dependant Nox1 activity in Vascular smooth muscle cells. 2013-2014.
  • C.I. NIH – R01HL079207 Reactive oxygen species in vascular disease Co-investigador NIH 2010-2013.
  • PostDoctoral Associate.  NIH – R01HL085134. Role of caveolin-1 and eNOS in mediating the therapeutics effects of CO in PAH. 2008-2010.
  • Research Associate. NIH – R01NS046423. Regulation of synaptic plasticity in hippocampus in vivo. 2007-2008.
  • PostGrafuate Student.  Fondecyt Iniciación1040809. Efecto de los inhibidores de la enzima convertidora de angiotrensina en las vias de señalizacion activadas por bradicinina en endotelio. 2004-2007.

Manuscripts

  1. Imad Al Ghouleh, Daniel N Meijles, Stephanie Mutchler, Qiangmin Zhang, Sanghamitra Sahoo, Anastasia Gorelova, Jefferson Henrich Amaral, Andrés I Rodríguez, Tatyana Mamonova, Gyun Jee Song, Alessandro Bisello, Peter A Friedman, M Eugenia Cifuentes-Pagano, Patrick J Pagano: Binding of EBP50 to Nox organizing subunit p47phox is pivotal to cellular reactive species generation and altered vascular phenotype. Proceedings of the National Academy of Sciences 08/2016; 113(36)., DOI:10.1073/pnas.1514161113
  2. Leonardo Y. Tanaka, Haniel A. Araújo, Gustavo K. Hironaka, Thaís L.S Araujo, Celso K. Takimura, Andres I. Rodriguez, Annelise S. Casagrande, Paulo S. Gutierrez, Pedro Alves Lemos-Neto, Francisco R.M. Laurindo: Peri/Epicellular Protein Disulfide Isomerase Sustains Vascular Lumen Caliber Through an Anticonstrictive Remodeling Effect. Hypertension 01/2016;, DOI:10.1161/HYPERTENSIONAHA.115.06177
  3. Andrés I Rodríguez, Gábor Csányi, Daniel J Ranayhossaini, Douglas M Feck, Kory J Blose, Lillian Assatourian, David A Vorp, Patrick J Pagano: MEF2B-Nox1 Signaling Is Critical for Stretch-Induced Phenotypic Modulation of Vascular Smooth Muscle Cells. Arteriosclerosis Thrombosis and Vascular Biology 12/2014; 35(2)., DOI:10.1161/ATVBAHA.114.304936
  4. Andres I Rodriguez, Francisco M Laurindo: Dynamic Interaction between Protein Disulfide Isomerase A1, Rac1 and Its Regulator RhoGDI during Nox1 NADPH Oxidase-Dependent Vascular Smooth Muscle Cell Migration. Free Radical Biology and Medicine 11/2014; 76:S73., DOI:10.1016/j.freeradbiomed.2014.10.354
  5. Leonardo Yuji Tanaka, Haniel Alves Araújo, Gustavo Ken Hironaka, Thais Larissa Araújo, Andres Ignacio Rodriguez, Annelise Silva Casagrande, Celso Kiyoshi Takimura, Francisco Rafael Laurindo: Peri/epicellular Protein Disulfide Isomerase Reshapes Vascular Architecture to Counteracts Constrictive Remodeling. Free Radical Biology and Medicine 11/2014; 76:S54., DOI:10.1016/j.freeradbiomed.2014.10.425
  6. Mingyi Yao, Natasha M Rogers, Gábor Csányi, Andres I Rodriguez, Mark A Ross, Claudette St Croix, Heather Knupp, Enrico M Novelli, Angus W Thomson, Patrick J Pagano, Jeffrey S Isenberg: Thrombospondin-1 Activation of Signal-Regulatory Protein- Stimulates Reactive Oxygen Species Production and Promotes Renal Ischemia Reperfusion Injury. Journal of the American Society of Nephrology 02/2014; 25(6)., DOI:10.1681/ASN.2013040433
  7. Imad Al Ghouleh, Andrés I. Rodríguez, Gyun Jee Song, Alessandro Bisello, Hunter C. Champion, Patrick J. Pagano: PSS130. Scaffolding Protein EBP50 is Critical for Angiotensin II- Induced Vascular Nox1 Activation, Tissue Oxidation, and Hypertrophy. Free Radical Biology and Medicine 11/2013; 65:S67-S68., DOI:10.1016/j.freeradbiomed.2013.10.549
  8. Daniel J Ranayhossaini, Andres I Rodriguez, Sanghamitra Sahoo, Beibei B Chen, Rama K Mallampalli, Eric E Kelley, Gabor Csanyi, Mark T Gladwin, Guillermo Romero, Patrick J Pagano: Selective Recapitulation of Conserved and Non-Conserved Regions of Putative NOXA1 Activation Domain Confers Isoform-Specific Inhibition of Nox1 Oxidase, Attenuation of Endothelial Cell Nox and Migration.. Journal of Biological Chemistry 11/2013; 288(51)., DOI:10.1074/jbc.M113.521344
  9. Imad Al Ghouleh, Andrés Rodríguez, Patrick J Pagano, Gábor Csányi: Proteomic Analysis Identifies an NADPH Oxidase 1 (Nox1)-Mediated Role for Actin-Related Protein 2/3 Complex Subunit 2 (ARPC2) in Promoting Smooth Muscle Cell Migration. International Journal of Molecular Sciences 10/2013; 14(10):20220-35., DOI:10.3390/ijms141020220
  10. Eugenia Cifuentes-Pagano, Jaideep Saha, Gabor Csanyi, Imad Al Ghouleh, Sanghamitra Sahoo, Andres Rodriguez, Peter Wipf, Patrick J. Pagano, Erin M Skoda: Bridged tetrahydroisoquinolines as selective NADPH oxidase 2 (Nox2) inhibitors. Medicinal Chemistry Communication 06/2013; 4:1085., DOI:10.1039/C3MD00061C
  11. Gábor Csányi, Mingyi Yao, Andres I Rodriguez, Imad Al Ghouleh, Maryam Sharifi-Sanjani, Giovanna Frazziano, Huang Xiaojun, Eric E Kelley, Jeffrey S Isenberg, Patrick J Pagano: Thrombospondin-1 Regulates Blood Flow via CD47 Receptor Mediated Activation of NADPH Oxidase 1. Arteriosclerosis Thrombosis and Vascular Biology 10/2012; 32(12)., DOI:10.1161/ATVBAHA.112.300031
  12. J Agustin Cruz, Eileen M Bauer, Andres I Rodriguez, Archana Gangopadhyay, Nabil S Zeineh, Yinna Wang, Sruti Shiva, Hunter C Champion, Philip M Bauer: Chronic hypoxia induces right heart failure in caveolin-1-/- mice. AJP Heart and Circulatory Physiology 04/2012; 302(12):H2518-27., DOI:10.1152/ajpheart.01140.2011
  13. Imad Al Ghouleh, Giovanna Frazziano, Gabor Csanyi, Eric E. Kelley, Loreto a Egana, Andres I. Rodriguez, Gyun Jee Song, Alessandro Bisello, Patrick J. Pagano: Pathophysiological Concentrations of H2O2 Induce NADPH Oxidase 1 (Nox1)- and Apoptosis Signal Regulating Kinase 1 (Ask1)- Dependent Smooth Muscle Hypertrophy. Free Radical Biology and Medicine 11/2011; 51., DOI:10.1016/j.freeradbiomed.2011.10.085
  14. Daniel Ranayhossaini, Andres Rodriguez, Gabor Csanyi, Patrick Pagano: NoxA1ds: a Novel and Specific Inhibitor of NADPH Oxidase Isoform 1 (Nox1). Free Radical Biology and Medicine 11/2011; 51., DOI:10.1016/j.freeradbiomed.2011.10.464
  15. Andres I Rodriguez, Archana Gangopadhyay, Eric E Kelley, Patrick J Pagano, Brian S Zuckerbraun, Philip M Bauer: HO-1 and CO Decrease Platelet-Derived Growth Factor-Induced Vascular Smooth Muscle Cell Migration Via Inhibition of Nox1. Arteriosclerosis Thrombosis and Vascular Biology 10/2009; 30(1):98-104., DOI:10.1161/ATVBAHA.109.197822
  16. Andrés I Rodriguez, Karla Pereira-Flores, Romina Hernández-Salinas, Mauricio P Boric, Victoria Velarde: High glucose increases B1-kinin receptor expression and signaling in endothelial cells. Biochemical and Biophysical Research Communications 07/2006; 345(2):652-9., DOI:10.1016/j.bbrc.2006.04.127
  17. Juan Diego Maya, Andrés Rodríguez, Laura Pino, Adriana Pabón, Jorge Ferreira, Mario Pavani, Yolanda Repetto, Antonio Morello: Effects of buthionine sulfoximine nifurtimox and benznidazole upon trypanothione and metallothionein proteins in Trypanosoma cruzi. Biological research 02/2004; 37(1):61-9., DOI:10.4067/S0716-97602004000100007
  18. Juan Diego Maya Arango, Antonio Morello Casté, Yolanda Repetto, A. Rodríguez, P. Puebla I, Esther Caballero S, Manuel Medarde, Luis J. Núñez Vergara, Juan A. Squella, María Eugenia Ortíz Yáñez, Jorge Fuentealba, Arturo San Feliciano: Trypanosoma cruzi: Inhibition of Parasite Growth and Respiration by Oxazolo(thiazolo)pyridine Derivatives and Its Relationship to Redox Potential and Lipophilicity. Experimental Parasitology 10/2001; 99(1)., DOI:10.1006/expr.2001.4638
  19. Juan Diego Maya, Antonio Morello, Yolanda Repetto, Rowena Tellez, Andrés Rodriguez, Ursula Zelada, Pilar Puebla, Esther Caballero, Manuel Medarde, Luis J Núñez-Vergara, Juan A Squella, Marcela Bontá, Soledad Bollo, Arturo San Feliciano: Effects of 3-chloro-phenyl-1,4-dihydropyridine derivatives on Trypanosome cruzi epimastigotes. Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology 02/2000; 125(1-125):103-109., DOI:10.1016/S0742-8413(99)00096-1

Book Chapters

  • 2018 Guillermo Petzold, Andrés Rodríguez, Roberto Valenzuela, Jorge Moreno and Karla Mella. Alginate as a versatile polymer matrix with biomedical and food applications.  Sensing fluid-shear stress in the endothelial system with a special emphasis in primary cillu
  • 2018 Meriem Rezgaouil, Andrés Rodríguez, Kurt Hertlitz, Carlos Escudero. Sensing fluid-shear stress in the endothelial system with a special emphasis in primary cillum.  Endothelial Dysfunction. ISNB 978-953-51-5698-7