Abstract Mesenchymal stem cells (MSCs) are adult multipotent stem cells that are able to differentiate into multiple specialized cell types including osteocytes, adipocytes, and chondrocytes. MSCs exert different functions in the body and have recently been predicted to have a major clinical/th...
Acurio J1, Herlitz K1, Troncoso F1, Aguayo C2,3, Bertoglia P4, Escudero C5,6. Abstract We aim to investigate whether A2A/nitric oxide-mediated regulation of vascular endothelial growth factor (VEGF) expression is impaired in feto-placental endothelial cells from late-onset pre-eclampsia...
Abstract HIGHLIGHTS Short-term incubation with insulin increases the L-arginine transport in HUVECs.Short-term incubation with insulin increases the NO synthesis in HUVECs.Insulin induces relaxation in human placental vascular bed.Insulin attenuates the constriction induced by hydrogen peroxid...
Cid M1, González M2. Abstract Changes in quality of nutrition, habits, and physical activity in modern societies increase susceptibility to obesity, which can deleteriously affect pregnancy outcome. In particular, a sedentary lifestyle causes dysfunction in blood flow, which impacts the card...
Dubó S1, Gallegos D2, Cabrera L3, Sobrevia L4, Zúñiga L5, González M6. Abstract Impairment of insulin signaling on diabetes mellitus has been related to cardiovascular dysfunction, heart failure, and sudden death. In human endothelium, cationic amino acid transporter 1 (hCAT-1) is r...
Sobrevia L1, Salsoso R2, Fuenzalida B3, Barros E3, Toledo L3, Silva L3, Pizarro C3, Subiabre M3, Villalobos R3, Araos J3, Toledo F4, González M5, Gutiérrez J6, Farías M3, Chiarello DI3, Pardo F3, Leiva A3. Abstract Gestational diabetes mellitus (GDM) is a disease of the mo...

RESUMEN: La vasculogénesis es controlada por una serie de mecanismos que se activan en función del tiempo y del espaciodurante el desarrollo embrionario. Múltiples son las vías de señalización implicadas en las etapas del proceso vasculogénico, las que seinician con estímulos angiogénico...

A large number of publications have described impaired angiogenesis and vasculogenesis present in the feto-placental circulation after pregnancy diseases such as pre-eclamptic pregnancies, gestational diabetes, and intrauterine growth restriction, among others. Results suggest impaired secretion and...
Escudero C1, Celis C2, Saez T3, San Martin S3, Valenzuela FJ2, Aguayo C4, Bertoglia P5, Roberts JM6, Acurio J2. Abstract INTRODUCTION: Placentas from both early-onset (EOPE) and late-onset pre-eclampsia (LOPE) exhibit signs of underperfusion, which in turn, may be associated with alte...
Abstract To investigate the functionality of A2B adenosine receptor (A2BAR) and the nitric oxide (NO) and vascular endothelial growth factor (VEGF) signaling pathway in the endothelial cell proliferation/migration during preeclampsia, we used human umbilical vein endothelial cells (HUVECs) isola...